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Chitlange, S. S.
- Simultaneous Spectrophotometric Estimation of Ofloxacin and Satranidazole in Tablet Dosage Form
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1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18, IN
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-18, IN
Source
Asian Journal of Research in Chemistry, Vol 1, No 1 (2008), Pagination: 9-11Abstract
Two accurate, precise, rapid and economical methods were developed for the estimation of Ofloxacin and Satranidazole in tablet dosage form. First method is first order derivative spectroscopy, wavelengths selected for quantitation were 259.0 nm for Ofloxacin (zero cross for Satranidazole) and 227.0 nm for Satranidazole (zero cross for Ofloxacin). Second method is area under curve method; area under curve in the range of 292.5-282.5 nm (for Ofloxacin) and 325.0-315.0 nm (for Satranidazole) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 5-40 μg/ml for Ofloxacin and Satranidazole, both. The proposed methods were successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.Keywords
Ofloxacin, Satranidazole, Derivative Spectroscopy, Area Under Curve Method.- Stability Indicating RP-HPLC Method for Simultaneous Estimation of Valsartan and Amlodipine in Capsule Formulation
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Authors
Affiliations
1 Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-411018, IN
2 S. N. Institute of Pharmacy, Pusad, IN
1 Dr. D.Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-411018, IN
2 S. N. Institute of Pharmacy, Pusad, IN